Two weeks ago, I attended a mini-seminar from Metagenics on the use of Specialized Pro-resolving Mediators (SPMs) for the resolution of inflammation.
As you may know, inflammation is an immune response to insults such as injuries (cuts, wounds, vertebral and extremity misalignments, muscle spasms, infections (bacterial, viral or fungal) or unhealthy dietary patterns.
Although acute inflammation is a normal protective response, it can give rise to chronic inflammation if left unresolved.
Extensive research suggests that the SPMs found in OmegaGenics SPM Active (17-HDHA and 18- HEPE) may promote the body’s natural resolution of the immune response. The research has discovered that SPMs are produced at the inflamed site after the initial inflammatory response and function as “resolution agonists,” orchestrating resolution to facilitate the return to homeostasis and tissue healing. http://www.metagenics.com/spm-active-specialized-pro-resolving-mediators
An important key to controlling/resolving inflammation and subsequently preventing chronic inflammatory conditions lies in SPMs and their pro-resolving properties.
SPMs are produced from long-chain polyunsaturated fatty acids – especially EPA and DHA – illustrating the importance of appropriate nutrition in the body’s resolution of inflammation.
Although EPA and DHA are metabolic precursors of SPMs, SPMs are directly responsible for resolution activities whereas EPA/DHA are involved in other beneficial biological activities.
This means that a smaller amount of SPMs can resolve inflammation better than a “ton” of EPA/DHA.
Please see the following video: Fish Oils vs SPMs: What’s the Difference?
Anti-inflammatory drugs (NSAID’s) have been the go-to therapy for many acute and chronic inflammatory conditions. However, anti-inflammation is not the same as pro-resolution.
To put it another way, NSAID’s shut off the fire alarm signaling inflammation while SPMs put out the fire.
In fact, NSAID’s may delay resolution activities and undermine the body’s attempt return to homeostasis and tissue healing. Unresolved inflammation and unhealed tissue can lead to fibrosis that can impair organ and muscle function.
In fact, a recent research paper review http://www.medscape.com/viewarticle/853216 Is Long-Term NSAID Use Harmful to Athletes? noted “Most recent reviews have come down on the side of restricting the use of NSAIDs, pending more information “Anti-inflammatory drugs seem to inhibit the healing process of connective tissue and the stimulating effect of exercise on connective tissue protein synthesis,” concluded the authors of a 2014 review in the journal Connective Tissue Research.”
And the paper also noted, ”One reason for caution is that NSAIDs can cause many side effects, including kidney disease, asthma exacerbation, gastrointestinal and renal side-effects, hypertension, and other cardiovascular diseases, in addition to whatever effects they have on muscle.”
SPM Active is a revolutionary nutritional product developed through advanced fractionation technology featuring standardized levels of SPMs (specialized pro-resolving mediators) found in fish oil.† Designed to support the body’s natural capacity to respond to physical challenges and resolve physical stress.*
- A breakthrough in tissue health and immune response support*
- Supports healthy immune cell (i.e., macrophage) resolution-related activities*
For more on a integrative approach to resolving inflammation, please read https://drvittoriarepetto.wordpress.com/2015/07/18/chronic-inflammation-and-how-chiropractic-applied-kinesiology-can-help/
If you have any questions about SPMs and resolving inflammation, feel free to give me a call at 212-431-3724 or email me at firstname.lastname@example.org
© 2015-Dr. Vittoria Repetto
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